Electrocardiography  is a transthoracic interpretation of the electrical  activity of the heart over time captured and externally recorded by skin  electrodes. It is a noninvasive recording produced by an electrocardiographic  device. The etymology of the word is derived from the Greek electro, because it  is related to electrical activity, cardio, Greek for heart, and graph, a Greek  root meaning "to write". In English speaking countries, medical professionals  often write EKG (the German abbreviation) in order to avoid confusion with  EEG.
The ECG works mostly by detecting and amplifying the tiny electrical  changes on the skin that are caused when the heart muscle "depolarises" during  each heart beat. At rest, each heart muscle cell has a charge across its outer  wall, or cell membrane. Reducing this charge towards zero is called  de-polarisation, which activates the mechanisms in the cell that cause it to  contract. During each heartbeat a healthy heart will have an orderly progression  of a wave of depolarisation that is triggered by the cells in the sinoatrial  node, spreads out through the atrium, passes through "intrinsic conduction  pathways" and then spreads all over the ventricles. This is detected as tiny  rises and falls in the voltage between two electrodes placed either side of the  heart which is displayed as a wavy line either on a screen or on paper. This  display indicates the overall rhythm of the heart and weaknesses in different  parts of the heart muscle.
Usually more than 2 electrodes are used and they can be combined into a  number of pairs. (For example: Left arm (LA),right arm (RA) and left leg (LL)  electrodes form the pairs: LA+RA, LA+LL, RA+LL) The output from each pair is  known as a lead. Each lead is said to look at the heart from a different angle.  Different types of ECGs can be referred to by the number of leads that are  recorded, for example 3-lead, 5-lead or 12-lead ECGs (sometimes simply "a  12-lead"). A 12-lead ECG is one in which 12 different electrical signals are  recorded at approximately the same time and will often be used as a one-off  recording of an ECG, typically printed out as a paper copy. 3- and 5-lead ECGs  tend to be monitored continuously and viewed only on the screen of an  appropriate monitoring device, for example during an operation or whilst being  transported in an ambulance. There may, or may not be any permanent record of a  3- or 5-lead ECG depending on the equipment used.
It is the best way to measure and diagnose abnormal rhythms of the  heart,particularly abnormal rhythms caused by damage to the conductive tissue  that carries electrical signals, or abnormal rhythms caused by electrolyte  imbalances. In a myocardial infarction (MI), the ECG can identify if the heart  muscle has been damaged in specific areas, though not all areas of the heart are  covered. The ECG cannot reliably measure the pumping ability of the heart, for  which ultrasound-based (echocardiography) or nuclear medicine tests are used. It  is possible to be in cardiac arrest with a normal ECG signal (a condition known  as pulseless electrical activity).
Muirhead is reported to have attached wires to a feverish patient's wrist  to obtain a record of the patient's heartbeat while studying for his Doctor of  Science -in electricity in 1872 at St Bartholomew's Hospital. This activity was  directly recorded and visualized using a Lippmann capillary electrometer by the  British physiologist John Burdon Sanderson. The first to systematically approach  the heart from an electrical point-of-view was Augustus Waller, working in St  Mary's Hospital in Paddington, London. His electrocardiograph machine consisted  of a Lippmann capillary electrometer fixed to a projector. The trace from the  heartbeat was projected onto a photographic plate which was itself fixed to a  toy train. This allowed a heartbeat to be recorded in real time. In 1911 he  still saw little clinical application for his work.
An initial breakthrough came when Willem Einthoven, working in Leiden,  Netherlands, used the string galvanometer that he invented in 1903. This device  was much more sensitive than both the capillary electrometer that Waller used  and the string galvanometer that had been invented separately in 1897 by the  French engineer Clément Ader.. Rather than using today's self-adhesive  electrodes Einthoven's subjects would immerse each of their limbs into  containers of salt solutions from which the ECG was recorded.
Einthoven assigned the letters P, Q, R, S and T to the various deflections,  and described the electrocardiographic features of a number of cardiovascular  disorders. In 1924, he was awarded the Nobel Prize in Medicine for his  discovery.
Though the basic principles of that era are still in use today, there have  been many advances in electrocardiography over the years. The instrumentation,  for example, has evolved from a cumbersome laboratory apparatus to compact  electronic systems that often include computerized interpretation of the  electrocardiogram.
The output of an ECG recorder is a graph (or sometimes several graphs,  representing each of the leads) with time represented on the x-axis and voltage  represented on the y-axis. A dedicated ECG machine would usually print onto  graph paper which has a background pattern of 1mm squares (often in red or  green), with bold divisions every 5mm in both vertical and horizontal  directions. It is possible to change the output of most ECG devices but it is  standard to represent each mV on the y axis as 1 cm and each second as 25mm on  the x-axis (that is a paper speed of 25mm/s). Faster paper speeds can be used -  for example to resolve finer detail in the ECG. At a paper speed of 25 mm/s, one  small block of ECG paper translates into 40 ms. Five small blocks make up one  large block, which translates into 200 ms. Hence, there are five large blocks  per second. A calibration signal may be included with a record. A standard  signal of 1 mV must move the stylus vertically 1 cm, that is two large squares  on ECG paper.
By definition a 12-lead ECG will show a short segment of the recording of  each of the 12-leads. This is often arranged in a grid of 4 columns by three  rows, the first columns being the limb leads , the second column the augmented  limb leads (aVR, aVL and aVF) and the last two columns being the chest leads .  It is usually possible to change this layout so it is vital to check the labels  to see which lead is represented. Each column will usually record the same  moment in time for the three leads and then the recording will switch to the  next column which will record the heart beats after that point. It is possible  for the heart rhythm to change between the columns of leads. Each of these  segments is short, perhaps 1-3 heart beats only, depending on the heart rate and  it can be difficult to analyse any heart rhythm that shows changes between heart  beats. To help with the analysis it is common to print one or two "rhythm  strips" as well. This will usually be lead II (which shows the electrical signal  from the atrium, the P-wave, well) and shows the rhythm for the whole time the  ECG was recorded (usually 5–6 seconds). The term "rhythm strip" may also refer  to the whole printout from a continuous monitoring system which may show only  one lead and is either initiated by a clinician or in response to an alarm or  event.
By definition a 12-lead ECG will show a short segment of the recording of  each of the 12-leads. This is often arranged in a grid of 4 columns by three  rows, the first columns being the limb leads , the second column the augmented  limb leads (aVR, aVL and aVF) and the last two columns being the chest leads .  It is usually possible to change this layout so it is vital to check the labels  to see which lead is represented. Each column will usually record the same  moment in time for the three leads and then the recording will switch to the  next column which will record the heart beats after that point. It is possible  for the heart rhythm to change between the columns of leads. Each of these  segments is short, perhaps 1-3 heart beats only, depending on the heart rate and  it can be difficult to analyse any heart rhythm that shows changes between heart  beats. To help with the analysis it is common to print one or two "rhythm  strips" as well. This will usually be lead II (which shows the electrical signal  from the atrium, the P-wave, well) and shows the rhythm for the whole time the  ECG was recorded (usually 5–6 seconds). The term "rhythm strip" may also refer  to the whole printout from a continuous monitoring system which may show only  one lead and is either initiated by a clinician or in response to an alarm or  event.
The term "lead" in electrocardiography causes much confusion because it is  used to refer to two different things. In accordance with common parlance the  word lead may be used to refer to the electrical cable attaching the electrodes  to the ECG recorder. As such it may be acceptable to refer to the "left arm  lead" as the electrode (and its cable) that should be attached at or near the  left arm. There are usually ten of these electrodes in a standard "12-lead"  ECG.
Alternatively (and some would say properly, in the context of  electrocardiography) the word lead may refer to the tracing of the voltage  difference between two of the electrodes and is what is actually produced by the  ECG recorder. Each will have a specific name. For example "Lead I" (lead one) is  the voltage between the right arm electrode and the left arm electrode, whereas  "Lead II" (lead two) is the voltage between the right limb and the feet. (This  rapidly becomes more complex as one of the "electrodes" may in fact be a  composite of the electrical signal from a combination of the other electrodes.  (See later.) Twelve of this type of lead form a "12-lead" ECG
To cause additional confusion the term "limb leads" usually refers to the  tracings from leads I, II and III rather than the electrodes attached to the  limbs.
Interpretation of the ECG relies on the idea that different leads (by which  we mean the ECG leads I,II,III, aVR, aVL, aVF and the chest leads) "view" the  heart from different angles. This has two benefits. Firstly, leads which are  showing problems (for example ST segment elevation) can be used to infer which  region of the heart is affected. Secondly, the overall direction of travel of  the wave of depolarisation can also be inferred which can reveal other problems.  This is termed the cardiac axis . Determination of the cardiac axis relies on  the concept of a vector which describes the motion of the depolarisation wave.  This vector can then be described in terms of its components in relation to the  direction of the lead considered. One component will be in the direction of the  lead and this will be revealed in the behaviour of the QRS complex and one  component will be at 90 degrees to this (which will not). Any net positive  deflection of the QRS complex (i.e. height of the R-wave minus depth of the  S-wave) suggests that the wave of depolarisation is spreading through the heart  in a direction that has some component (of the vector) in the same direction as  the lead in question.
The heart's electrical axis refers to the general direction of the heart's  depolarization wavefront (or mean electrical vector) in the frontal plane. With  a healthy conducting system the cardiac axis is related to where the major  muscle bulk of the heart lies. Normally this is the left ventricle with some  contribution from the right ventricle. It is usually oriented in a right  shoulder to left leg direction, which corresponds to the left inferior quadrant  of the hexaxial reference system, although −30° to +90° is considered to be  normal. If the left ventricle increases its activity or bulk then there is said  to be "left axis deviation" as the axis swings round to the left beyond -30°,  alternatively in conditions where the right ventricle is strained or  hypertrophied then the axis swings round beyond +90° and "right axis deviation"  is said to exist. Disorders of the conduction system of the heart can disturb  the electrical axis without necessarily reflecting changes in muscle bulk.
In addition, any two precordial leads that are next to one another are  considered to be contiguous. For example, even though V4 is an anterior lead and  V5 is a lateral lead, they are contiguous because they are next to one  another.
Lead aVR offers no specific view of the left ventricle. Rather, it views  the inside of the endocardial wall to the surface of the right atrium, from its  perspective on the right shoulder.
Modern ECG monitors offer multiple filters for signal processing. The most  common settings are monitor mode and diagnostic mode. In monitor mode, the low  frequency filter- the high-pass filter because signals above the threshold are  allowed to pass) is set at either 0.5 Hz or 1 Hz and the high frequency filter  (also called the low-pass filter because signals below the threshold are allowed  to pass) is set at 40 Hz. This limits artifact for routine cardiac rhythm  monitoring. The high-pass filter helps reduce wandering baseline and the  low-pass filter helps reduce 50 or 60 Hz power line noise (the power line  network frequency differs between 50 and 60 Hz in different countries). In  diagnostic mode, the high-pass filter is set at 0.05 Hz, which allows accurate  ST segments to be recorded. The low-pass filter is set to 40, 100, or 150 Hz.  Consequently, the monitor mode ECG display is more filtered than diagnostic  mode, because its passband is narrower
Murmurs are extra heart sounds that are produced as a result of turbulent  blood flow that is sufficient to produce audible noise. Most murmurs can only be  heard with the assistance of a stethoscope ("on auscultation").
A functional murmur or "physiologic murmur" is a heart murmur that is  primarily due to physiologic conditions outside the heart, as opposed to  structural defects in the heart itself. Functional murmurs may be benign (an  "innocent murmur")[1], mildly troublesome, or serious.
Murmurs may also be the result of various problems, such as narrowing or  leaking of valves, or the presence of abnormal passages through which blood  flows in or near the heart. Such murmurs, known as pathologic murmurs, should be  evaluated by an expert.
Heart murmurs are most frequently organized by timing, into systolic heart  murmurs and diastolic heart murmurs. However, continuous murmurs cannot be  directly placed into either category
Murmurs can be classified by seven different characteristics: timing,  shape, location, radiation, intensity, pitch and quality.
Timing refers to whether the murmur is a systolic or diastolic murmur.  
Shape refers to the intensity over time; murmurs can be crescendo,  decrescendo or crescendo-decrescendo. 
Location refers to where the heart murmur is usually auscultated best.  There are six places on the anterior chest to listen for heart murmurs; each of  the locations roughly corresponds to a specific part of the heart. The first  five of the six locations are adjacent to the sternum. The six locations are:  
the 2nd right intercostal space 
the 2nd to 5th left intercostal spaces 
the 5th mid-clavicular intercostal space. 
Radiation refers to where the sound of the murmur radiates. The general  rule of thumb is that the sound radiates in the direction of the blood flow.  
Intensity refers to the loudness of the murmur, and is graded on a scale  from 0-6/6. 
Pitch can be low, medium or high and is determined by whether it can be  auscultated best with the bell or diaphragm of a stethoscope. 
Quality refers to unusual characteristics of a murmur, such as blowing,  harsh, rumbling or musical.
 
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